(i)
| Hormone | Disorder | Gland |
|---|---|---|
| (I) Over-secretion of Growth Hormone | Gigantism (in children) / Acromegaly (in adults) | Pituitary gland |
| (II) Deficiency of Oestrogen | Osteoporosis / irregular menstrual cycle | Ovary |
| (III) Less secretion of Thyroxine | Goitre / Hypothyroidism | Thyroid gland |
(ii) Regulation of Hormone Release — Feedback Mechanism:
The timing and amount of hormone released is regulated by a feedback mechanism.
Example: When blood sugar rises, the pancreas secretes more insulin, which lowers blood glucose. When blood sugar returns to normal, further secretion of insulin is stopped. This self-regulating loop — where the effect of the hormone feeds back to control its own secretion — is called negative feedback.
Similarly, if thyroid hormone levels fall, the pituitary releases TSH to stimulate the thyroid; once levels are normal, TSH secretion decreases.
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