Option D: Cytoplasm and Mitochondria
Breakdown of glucose to pyruvate occurs in the cytoplasm, and further breakdown of pyruvate to carbon dioxide (aerobic respiration) occurs in the mitochondria.
The textbook (Section 5.3) clearly states: "The first step is the break-down of glucose into pyruvate — this takes place in the cytoplasm. Break-down of pyruvate using oxygen takes place in the mitochondria." This is a frequently asked fact; remember the sequence: Cytoplasm → Mitochondria for aerobic respiration.